Praziquantel efficacy is highest when the infection is parasitologically confirmed and the drug is dosed over three consecutive days. In a cohort of 151 people with fluke-related liver lesions, the three-day regimen cured 90.0 percent of confirmed cases. Cure rates climbed slowly, reaching 76.9 percent only at 90 days. Short follow-up windows understate how well the drug works. Why praziquantel efficacy still leaves practical questions open Flukes of the genus Clonorchis are foodborne trematodes. People pick them up by eating raw freshwater fish. Chronic infection triggers periductal fibrosis, biliary hyperplasia, and focal eosinophilic infiltration, and the organism sits in the World Health Organization’s Group 1 carcinogen list. On imaging the…