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Piroxicam vs Dexamethasone for Glioblastoma: Which Preserves Immune Function?
Glioblastoma is one of the hardest cancers to treat. Even with surgery, radiation, and chemo, patients live about 15 months on average. But there is something that does not get talked about enough: the drugs used to manage symptoms might actually be hurting the immune system. Dexamethasone, a strong corticosteroid, is standard for glioblastoma patients. It reduces brain swelling and helps with chemo side effects. It works. The catch is that dexamethasone also suppresses T cells. In a cancer where the immune system is already running on fumes, that extra suppression matters. Studies have found that high-dose dexamethasone (over 8 mg/kg) is linked to shorter survival in both animals and…


