The Real Problem with Antibiotic Solutions If you have ever formulated antibiotics, you know the drill. You get everything dialed in, the solution looks perfect, then a week later the potency has dropped off a cliff. Oxytetracycline hydrochloride is notorious for this. It is a solid antibiotic, widely used, but its chemistry makes it a nightmare to keep stable in liquid form. The molecule has this complicated zwitterionic structure that basically falls apart when you look at it wrong. Water, light, pH shifts, temperature fluctuations. Any of these can trigger degradation. And it is not just an academic problem. When your drug degrades in the vial, patients get underdosed, treatment…