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Fenofibrate for Neuroprotection: Reprogramming Microglial Lipid Metabolism & Blocking Ferroptosis
Neuroinflammation sits at the center of some brutal neurological diseases — Alzheimer’s, Parkinson’s, multiple sclerosis, stroke. The trouble starts with microglia, the brain’s immune cells. When they go haywire, they stop protecting neurons and start destroying them. You get this runaway loop of inflammation, oxidative stress, and cell death that accelerates everything. But what if a drug that’s been sitting on pharmacy shelves for decades — one people take for high cholesterol — could interrupt that whole cycle? That’s the question researchers have been chasing with fenofibrate, a PPAR-alpha agonist that’s been used to treat dyslipidemia since the 1970s. The results are genuinely surprising. Fenofibrate does a lot more than…


