A sanguinarine feed additive built from Macleaya cordata lifted average daily gain in lambs from 75.71 to 155.71 grams per day over 28 days. Serum IgG, IL-6 and IFN-gamma all came up. IL-4 and IL-10 went down. Blautia abundance dropped hard. The arachidonic acid pathway came out reworked. Which immune signature you get depends on the dose. What a sanguinarine feed additive does in a lamb, in one paragraph Sanguinarine (SNG) belongs to the benzophenanthridine alkaloids. The commercial form is a Macleaya cordata extract, and growers have used the plant for years as a source of antimicrobial alkaloids. Pigs and broilers already have a decade of published work on a…