Sheep mange treatment fails on many farms not because the drugs are weak, but because the flock carries the problem invisibly. A 2026 study of 320 Barki ewes found that infected sheep show a strong systemic signature, with immune genes like IL33 rising 2.17 times, antioxidant genes like SLC7A11 falling to 0.43, acute phase proteins climbing sharply, and 14 gene variants distributed differently between affected and healthy animals. Sheep mange treatment works best when it targets the whole flock, repeats at the right interval, and addresses the reservoirs that reinfest clean animals. Why mange keeps defeating good treatment plans Mange is the most common external parasitic disease of sheep in…