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Theileria drug resistance: targeting the mitochondria
Theileria drug resistance is spreading because bovine theileriosis treatment leans on a single drug, buparvaquone. A drug-repurposing screen of the Global Health Priority Box found that rotenone kills Theileria annulata infected cells, keeps working against buparvaquone-resistant cells, and collapses their mitochondrial energy supply. That makes mitochondrial bioenergetics a resistance-independent target for next-generation antiparasitic drugs. Why theileria drug resistance has become a livestock problem Bovine theileriosis is a severe tick-borne disease, and Theileria annulata is the parasite behind it across tropical and subtropical regions. Herds pay for the infection in mortality, reduced milk yield, lost productivity and reproductive impairment. Commercial operations feel it most, because they have no second drug class…
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Disease resistance in aquaculture: 110 days of feeding
European seabass juveniles fed a mushroom-derived additive for 110 days survived a bacterial challenge better than controls. The 1 and 2 percent diets gave the clearest change in immune gene expression and plasma enzyme activity. Disease resistance in aquaculture works on a slow clock, and the 2 and 50 day samples showed nothing at all. Why disease resistance in aquaculture is a feed decision now Global aquaculture production reached 103 million tonnes in 2024, which works out at 53 percent of total aquatic animal production. Marine finfish account for a large share of that figure, and they are grown in pens where one bacterial outbreak can end a production cycle…
